2-Acetylpyridine → 2-Hydroxy-4-oxo-4-pyridin-2-ylbutyric acid ethyl ester

HRID 499149

반응식

HRID 499149 반응식
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[O:3].[C:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)(=[O:10])[CH3:9]>C1(C)C=CC=CC=1>[CH2:6]([O:5][C:1](=[O:4])[CH:2]([OH:3])[CH2:9][C:8](=[O:10])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[CH3:7]

참가 물질

4

반응물 2

HCID 142862-AcetylpyridineHCID 70211Ethyl oxoacetate

생성물 1

HCID 675234202-Hydroxy-4-oxo-4-pyridin-2-ylbutyric acid ethyl ester수율 44%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
135 °C

실험 절차

A mixture of ethyl glyoxalate (3.060 g, 30.000 mmol) (6.2 mL of a 50% solution in toluene) and 2-acetylpyridine (3.630 g, 30.000 mmol) was heated in an oil bath at 135° C. for 16 hours. The crude residue after removal of toluene was purified by column chromatography. The pure 2-hydroxy-4-oxo-4-pyridin-2-ylbutyric acid ethyl ester was isolated in 44% yield (2.910 g, 13.000 mmol).

후처리

  1. customThe crude residue after removal of toluene
  2. customwas purified by column chromatography

출처 및 근거

ORD 기록
ord-cb01fbafd5a64462b5daf05bb07ec02c
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767677B2

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