Pyridine-2-carbonitrile → HCID 59750340, 화합물

HRID 499270노트

반응식

HRID 499270 반응식
[CH3:1][O:2][C:3]1[C:4]([SH:12])=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=O.[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)#[N:14]>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[C:4]2[S:12][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[N:14][C:6](=[O:8])[C:5]=2[CH:9]=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 7522Pyridine-2-carbonitrileHCID 166556102-Mercapto-3-methoxybenzoic acid

생성물 1

HCID 59750340HCID 59750340, 화합물수율 28%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
135 °C

실험 절차

A mixture of 3-methoxy-2-mercaptobenzoic acid (1.84 g, 10.0 mmol), 2-cyanopyridine (1.05 g, 10.2 mmol) and pyridine (30.0 ml) was refluxed at 135° C. for 18 hrs as described in Example 9. The mixture was concentrated. The obtained crystals were recrystallized from ethanol to give the titled compound (0.75 g, 28%).

후처리

  1. concentrationThe mixture was concentrated
  2. customThe obtained crystals were recrystallized from ethanol

출처 및 근거

ORD 기록
ord-aa6d7a7476f4414b9e58fbba8e9dd439
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

반응 노트

불러오는 중…