Pyridine-2-carbonitrile → 7-methoxy-2-(2-pyridyl)-4H-1,3-benzothiazine-4-one

HRID 499300노트

반응식

HRID 499300 반응식
[SH:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)#[N:14]>N1C=CC=CC=1>[CH3:12][O:11][C:9]1[CH:8]=[CH:7][C:3]2[C:4](=[O:6])[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[S:1][C:2]=2[CH:10]=1

참가 물질

4

반응물 2

HCID 7522Pyridine-2-carbonitrileHCID 139616424-Methoxy-2-sulfanylbenzoic acid

생성물 1

HCID 597501107-methoxy-2-(2-pyridyl)-4H-1,3-benzothiazine-4-one수율 47%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 2-mercapto-4-methoxybenzoic acid (1.4 g, 7.9 mmol), 2-cyanopyridine (0.89 g, 8.5 mmol) and pyridine (10 ml) was refluxed for 10 hrs as described in Example 9. After cooling, the precipitated crystals were collected by filtration and recrystallized from hexane-tetrahydrofuran to give the titled compound (1.0 g, 47%) as crystals.

후처리

  1. temperaturewas refluxed for 10 hrs
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were collected by filtration
  4. customrecrystallized from hexane-tetrahydrofuran

출처 및 근거

ORD 기록
ord-5eecfc02d78b4f59b45d1416fb6018e4
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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