Lithium Hydroxide → 2-Methoxy-5-(thiophene-3-yl)benzoic acid
반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Li+]>C1(C)C=CC=CC=1.C(O)C.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]참가 물질
4
실험 절차
Methyl 2-Methoxy-5-(thiophene-3-yl)benzoate (124 mg) was dissolved in a solvent mixture of tetrahydrofuran/methanol/water (2/1/1, 3 ml). Lithium hydroxide (53 mg) was added to the obtained solution, and they were stirred overnight. The solvent was evaporated, and the residue was added to 3 N hydrochloric acid. The white solid thus precipitated was taken by the filtration as the title compound.
후처리
- customThe solvent was evaporated
- additionthe residue was added to 3 N hydrochloric acid
- customThe white solid thus precipitated
- filtrationwas taken by the filtration as the title compound
출처 및 근거
- ORD 기록
- ord-482ac188de284002a6553410a0302fe4
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06710056B2
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