Tetrahydrofuran → 2-Cyano-6-methylthiopyrazine

HRID 499554

반응식

HRID 499554 반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1.[CH3:10][S-:11].[Na+].C1COCC1.C(OCC)(=O)C>O>[C:8]([C:4]1[CH:5]=[N:6][CH:7]=[C:2]([S:11][CH3:10])[N:3]=1)#[N:9]

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 813036-Chloropyrazine-2-carbonitrileHCID 4378561Sodium methanethiolate

생성물 1

HCID 229392812-Cyano-6-methylthiopyrazine수율 83%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2-chloro-6-cyanopyrazine (1.40 g, 10.0 mmol), sodium thiomethoxide (0.78 g, 11.0 mmol) and THF (100 ml) was refluxed for 2 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated to give the titled compound (1.25 g, 83%) as pale yellow crystals.

후처리

  1. temperaturewas refluxed for 2 hrs
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-10c916b4118a4d4fb5af290e415fd27f
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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