Acetic Anhydride → 3-(2-Pyridyl)propyl acetate

HRID 499571

반응식

HRID 499571 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][OH:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>N1C=CC=CC=1>[C:11]([O:10][CH2:9][CH2:8][CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)(=[O:13])[CH3:12]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 72922Pyripropanol

생성물 1

HCID 234486323-(2-Pyridyl)propyl acetate수율 99.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-Pyridinepropanol (2.0 g, 14.6 mmol) was dissolved in pyridine (5 ml), and acetic anhydride (3.0 g, 29.2 mmol) was added thereto. The reaction mixture was stirred at room temperature for 2.5 hrs, and subjected to a silica gel (75 g) column chromatography. The fractions eluted with hexane-ethyl acetate (3:1, v/v) were collected and concentrated to give the titled compound (2.6 g, 99%).

후처리

  1. washThe fractions eluted with hexane-ethyl acetate (3:1
  2. customv/v) were collected
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c448b787721b4073b3743c225cff8fc7
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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