Diethyl Ether → N-[(3-{4-[(Acetylamino)methyl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]-5-chloro-2-thiophenecarboxamide

HRID 499738

반응식

HRID 499738 반응식
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][CH:19]([CH2:21][NH:22][C:23]([C:25]3[S:26][C:27]([Cl:30])=[CH:28][CH:29]=3)=[O:24])[O:18][C:17]2=[O:31])=[CH:12][CH:11]=1.CCOCC>C1COCC1.ClCCl.N1C=CC=CC=1>[C:1]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][CH:19]([CH2:21][NH:22][C:23]([C:25]3[S:26][C:27]([Cl:30])=[CH:28][CH:29]=3)=[O:24])[O:18][C:17]2=[O:31])=[CH:12][CH:11]=1)(=[O:3])[CH3:2]

참가 물질

7

반응물 3

HCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 21070786N-({3-[4-(aminomethyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)-5-chloro-2-thiophenecarboxamide

생성물 1

HCID 21070779N-[(3-{4-[(Acetylamino)methyl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]-5-chloro-2-thiophenecarboxamide

시약·촉매·용매 3

HCID 1049Pyridine용매HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

Acetic anhydride (0.015 ml, 0.164 mmol is added to a mixture of 30 mg (0.082 mmol) of N-({3-[4-(aminomethyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)-5-chloro-2-thiophenecarboxamide (from Example 148) in 1.5 ml of absolute THF and 1.0 ml of absolute dichloromethane, 0.02 ml of absolute pyridine at 0° C. The mixture is stirred at room temperature overnight. The product is obtained after addition of ether and crystallization. Yield: 30 mg (87% of theory),

후처리

  1. customThe product is obtained

출처 및 근거

ORD 기록
ord-e7999333e3964a3ea0404b75d0a57948
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767702B2

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