Sodium Bicarbonate → Aliskiren

HRID 500016노트

반응식

HRID 500016 반응식
C(OC(=O)[NH:7][C@@H:8]([CH2:26][C@H:27]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=1)[CH:28]([CH3:30])[CH3:29])[C@@H:9]([OH:25])[CH2:10][C@H:11]([C:15](=[O:24])[NH:16][CH2:17][C:18]([C:21](=[O:23])[NH2:22])([CH3:20])[CH3:19])[CH:12]([CH3:14])[CH3:13])(C)(C)C.C(=O)(O)[O-].[Na+]>Cl.O1CCOCC1>[NH2:7][C@@H:8]([CH2:26][C@H:27]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=1)[CH:28]([CH3:29])[CH3:30])[C@@H:9]([OH:25])[CH2:10][C@@H:11]([CH:12]([CH3:13])[CH3:14])[C:15]([NH:16][CH2:17][C:18]([C:21](=[O:23])[NH2:22])([CH3:20])[CH3:19])=[O:24]

참가 물질

5

반응물 2

HCID 516892Sodium BicarbonateHCID 53348234tert-Butyl [(3S,5S,6S,8S)-8-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-6-hydroxy-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-2,9-dimethyldecan-5-yl]carbamate

생성물 1

HCID 5493444Aliskiren

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

Product 13 is dissolved in a mixture of 4.0M hydrochloric acid in dioxane. The solution is stirred for 24 hours at room temperature and neutralized with solid sodium bicarbonate. The suspension is filtered and the solvent removed in vacuum to give the product as a foam (for characterization see e.g. EP 0 678 503, Example 137).

후처리

  1. filtrationThe suspension is filtered
  2. customthe solvent removed in vacuum

출처 및 근거

ORD 기록
ord-ab4596c6eae7472bb5bd1d8be44d3a6c
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767831B2

반응 노트

불러오는 중…