Methacryloyl chloride → 1,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate

HRID 500057

반응식

HRID 500057 반응식
[F:1][C:2]([F:14])([F:13])[C:3]([C:9]([F:12])([F:11])[F:10])([OH:8])[CH2:4][CH2:5][CH2:6][OH:7].C[Li].[CH2:17]([Li])CCC.[C:22](Cl)(=[O:26])[C:23]([CH3:25])=[CH2:24]>>[C:22]([O:7][CH2:6][CH:5]([CH3:17])[CH2:4][C:3]([C:9]([F:10])([F:11])[F:12])([OH:8])[C:2]([F:13])([F:14])[F:1])(=[O:26])[C:23]([CH3:25])=[CH2:24]

참가 물질

5

반응물 4

HCID 13528Methacryloyl chlorideHCID 218953625,5,5-Trifluoro-4-(trifluoromethyl)pentane-1,4-diolHCID 178418339ButyllithiumHCID 178418348HCID 178418348, 화합물

생성물 1

HCID 184437201,1,1-Trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate수율 76%

실험 절차

The title compound was prepared by method of Example 4, substituting 43 g (0.181 mol) of 1,1,1-trifluoro-2-trifluoromethyl-4-methyl-2,5-pentanediol (2) for 1,1,1-trifluoro-2-trifluoromethyl-2,5-pentanediol (4) and 226 mL (0.362 mol) of methyllithium (1.6M in ether) in lieu of the n-butyllithium, and using 20.7 g (0.199 mol) of methacryloyl chloride, to yield 35 g (76%) of the title compound as a clear colorless oil.

후처리

  1. customThe title compound was prepared by method of Example 4

출처 및 근거

ORD 기록
ord-25977dcb45444e15b2002fb7882159ff
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767866B2

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