4-Methylmorpholine → Dextroamphetamine

HRID 500349

반응식

HRID 500349 반응식
C1CCC(N=C=NC2CCCCC2)CC1.S(O)(O)(=O)=O.[NH2:21][CH:22]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH3:23].CN1CCOCC1>CN(C=O)C.O1CCOCC1.O>[CH3:23][C@H:22]([NH2:21])[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

참가 물질

5

반응물 3

HCID 79724-MethylmorpholineHCID 10868DicyclohexylcarbodiimideHCID 222898Amphedrine

생성물 1

HCID 5826Dextroamphetamine

시약·촉매·용매 1

HCID 86622776DMF dioxane water용매

실험 절차

O-Acetyl-l-carnitine·Cl (1.000 g, 4.17 mmol) was dissolved in 12.5 mL of a mixture of DMF/dioxane/water (2:2:1). NHS (0.528 g, 4.59 mmol) and DCC (0.947 g, 4.59 mmol) were added and the mixture was stirred overnight at ambient temperature. Solvents were evaporated and the remaining residue was dried overnight in high vacuum. The crude succinimidyl ester intermediate was dissolved in 20 mL of anhydrous DMF. Amphetamine sulfate (0.700 g, 1.90 mmol) and NMM (0.92 mL, 8.34 mmol) were added and the mixture stirred overnight. Solvent was evaporated to dryness and the remaining residue was leached with IPA. Solvent was evaporated to yield Carn-d-amphetamine.

후처리

  1. customSolvents were evaporated
  2. customthe remaining residue was dried overnight in high vacuum
  3. dissolutionThe crude succinimidyl ester intermediate was dissolved in 20 mL of anhydrous DMF
  4. stirringthe mixture stirred overnight
  5. customSolvent was evaporated to dryness
  6. customSolvent was evaporated

출처 및 근거

ORD 기록
ord-684be369b7ea4f9bb6157c8fc9ed90a1
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772222B2

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