Sodium borohydride → HCID 57528604, 화합물

HRID 500525노트

반응식

HRID 500525 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[C:10]([C:13](=[O:15])[CH3:14])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[C:10]([CH:13]([OH:15])[CH3:14])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 467019251-[5-(3-Chlorophenyl)-1,2-oxazol-3-yl]ethan-1-one

생성물 1

HCID 57528604HCID 57528604, 화합물수율 109.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a screw cap vial equipped with stir bar added the title compound of Example 6.1 (100 mg, 0.45 mmol), sodium borohydride (34 mg, 0.90 mmol) and methanol (3 mL). The resulting mixture was stirred at room temperature for 3 h. The reaction was quenched with water (30 mL) and brine (30 mL), extracted with dichloromethane (3 times 30 mL). The combined organic phase was dried (sodium sulfate), filtered and concentrated, in vacuo to isolate the title compound as a white solid (110 mg).

후처리

  1. customIn a screw cap vial
  2. customequipped
  3. stirringThe resulting mixture was stirred at room temperature for 3 h
  4. customThe reaction was quenched with water (30 mL) and brine (30 mL)
  5. extractionextracted with dichloromethane (3 times 30 mL)
  6. dry with materialThe combined organic phase was dried (sodium sulfate)
  7. filtrationfiltered
  8. concentrationconcentrated, in vacuo

출처 및 근거

ORD 기록
ord-38058b5b35264816b507ccc78975b40c
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772235B2

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