Hydrazine hydrate (1:1) → 6-Oxo-1-((2-(trimethylsilyl)ethoxy)methyl)-1,6-dihydropyridazine-4-carbohydrazide
반응식
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[C:10](=[O:12])[CH:11]=1)=O)C.O.[NH2:22][NH2:23]>C(O)C>[O:12]=[C:10]1[N:9]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[N:8]=[CH:7][C:6]([C:4]([NH:22][NH2:23])=[O:3])=[CH:11]1참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
The title compound from Example 19.2 (0.85 g, 2.8 mmol) was stirred in ethanol. Hydrazine hydrate (0.720 g, 14.2 mmol) was added to the solution and the reaction was stirred at 50° C. for 1 hour. The reaction was concentrated and triturated with methanol and diethyl ether to produce a precipitate which was collected by vacuum filtration as the title compound (0.56 g, 57%).