Methanol → N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine

HRID 500701노트

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HRID 500701 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16](F)=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8].[OH-:24].[Na+].[CH3:26]O>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:24][CH3:26])=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 10640649N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

생성물 1

HCID 21847811N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine

시약·촉매·용매 1

HCID 962Water용매2회

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온도
70 °C

실험 절차

(3-Chloro-4-fluoro-phenyl)-(7-fluoro-6-nitro-quinazolin-4-yl)-amine was suspended in 100 ml methanol and 2 ml 50% NaOH in water was added and the mixture was heated at 70° C. for 2 hours. The mixture was then poured into water and stirred vigorously for 30 minutes, then filtered and washed with water and dried under vacuum at 60° C. overnight to give 7.2 g of (3-Chloro-4-fluoro-phenyl)-(7-methoxy-6-nitro-quinazolin-4-yl)-amine.

후처리

  1. filtrationfiltered
  2. washwashed with water
  3. customdried under vacuum at 60° C. overnight

출처 및 근거

ORD 기록
ord-d9bb623f15084ae5ba21d1da3acb85b9
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772243B2

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