Thymine → 2-(5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acid

온도

0 °C

This procedure is different from the literature synthesis, but is easier, gives higher yields, and leaves no unreacted thymine in the product. To a suspension of thymine (3, 40 g, 0.317 mol) and potassium carbonate (87.7 g, 0.634 mmol) in DMF (900 mL) was added methyl bromoacetate (30 mL, 0.317 mmol). The mixture was stirred vigorously overnight under nitrogen. The mixture was filtered and evaporated to dryness, in vacuo. The solid residue was treated with water (300 mL) and 4 N hydrochloric acid (12 mL), stirred for 15 minutes at 0° C., filtered, and washed with water (2×75 mL). The precipitate was treated with water (120 mL) and 2 N sodium hydroxide (60 mL), and was refluxed for 10 minutes. The mixture was cooled to 0° C., filtered, and title compound was precipitated by the addition of 4 N hydrochloric acid (70 mL). The yield after drying, in vacuo over sicapent was 37.1 g (64%). 1H-NMR: (90 MHz; DMSO-d6): 11.33 ppm (s, 1H, NH); 7.49 (d, J=0.92 Hz, 1H, ArH); 4.38 (s, 2H, CH2); 1.76 (d, J=0.92 Hz, T-CH).

1. filtrationThe mixture was filtered
2. customevaporated to dryness, in vacuo
3. additionThe solid residue was treated with water (300 mL) and 4 N hydrochloric acid (12 mL)
4. stirringstirred for 15 minutes at 0° C.
5. filtrationfiltered
6. washwashed with water (2×75 mL)
7. additionThe precipitate was treated with water (120 mL) and 2 N sodium hydroxide (60 mL)
8. temperaturewas refluxed for 10 minutes
9. filtrationfiltered
10. customtitle compound was precipitated by the addition of 4 N hydrochloric acid (70 mL)
11. customThe yield
12. customafter drying, in vacuo

ORD 기록

ord-4e4a9ea5a5024b808473a4b857764424

출처 데이터셋

uspto-grants-2004_03

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06710164B1