Dimethylformamide → HCID 22024515, 화합물

HRID 500987노트

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HRID 500987 반응식
[Cl:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1.P(Cl)(Cl)(Cl)=O.CN(C)[CH:20]=[O:21]>>[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH:20]=[O:21])=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 120740798-Chloro-2-ethylimidazo[1,2-a]pyrazine

생성물 1

HCID 22024515HCID 22024515, 화합물

반응 조건

온도
90 °C

실험 절차

8-Chloro-2-ethylimidazo[1,2-a]pyrazine (600 mg, 3.3 mmol) was dissolved in N,N-dimethylformamide (3.3 mL), phosphorus oxychloride (1.2 mL, 13.2 mmol) was added dropwise at room temperature, and the mixture was heated under stirring at 90° C. for 2 hours. After being allowed to cool, the reaction mixture was poured into ice and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and evaporated to give the title compound (472 mg) as white crystals.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto cool
  3. additionthe reaction mixture was poured into ice
  4. extractionextracted with ethyl acetate
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-b2cae1935af54bd7b72b2b061af7a663
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772249B2

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