Sodium Hydroxide → HCID 22024679, 화합물

HRID 501007노트

반응식

HRID 501007 반응식
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][CH:8]([CH2:11][CH3:12])[CH2:9][OH:10])=[N:3][CH:2]=1.[Br:13]Br.[OH-].[Na+]>C(O)(=O)C>[Br:13][C:5]1[C:4]([NH:7][CH:8]([CH2:11][CH3:12])[CH2:9][OH:10])=[N:3][CH:2]=[N:1][CH:6]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 24408BromineHCID 220243971-Butanol, 2-(4-pyrimidinylamino)-

생성물 1

HCID 22024679HCID 22024679, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2-(4-Pyrimidinylamino)-1-butanol (4.2 g) was dissolved in acetic acid (42 mL), and bromine (1.5 mL) was added dropwise at a normal temperature. After stirred for 1 day at the same temperature, the solution was neutralized with a 5N aqueous sodium hydroxide solution and extracted with ethyl acetate, and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1.1) to give the title compound (4.4 g) as white crystals.

후처리

  1. extractionextracted with ethyl acetate
  2. customthe solvent was evaporated
  3. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1.1)

출처 및 근거

ORD 기록
ord-ce9896d298fa4e62bba5fbfba8c67826
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772249B2

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