1-Methyl-4-(4-nitrobenzyl)piperazine → 4-((4-Methylpiperazin-1-yl)methyl)aniline

HRID 501220

반응식

HRID 501220 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)[CH2:4][CH2:3]1>CO.[Ni]>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 1

HCID 6777951-Methyl-4-(4-nitrobenzyl)piperazine

생성물 1

HCID 31539964-((4-Methylpiperazin-1-yl)methyl)aniline수율 91.7%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

To a solution of 1-methyl-4-(4-nitrobenzyl)piperazine (4.0 g) in methanol (100 mL) at room temperature under nitrogen atmosphere was added Raney nickel (1.6 gm). The reaction mixture was stirred for 2 hr under hydrogen atmosphere. The progress of the reaction was monitored by TLC and upon completion of the reaction, the mixture was filtered under nitrogen atmosphere and the solvent was removed under reduced pressure to give 4-[(4-methylpiperazin-1-yl)methyl]aniline (3.2 g). 1H NMR (CDCl3, 200 MHz) δ: 7.13 (2H, d, J=8.4 Hz), 6.61 (2H, d, J=8.4 Hz), 3.41 (2H, s), 2.45 (8H, bm), 2.27 (3H, s); m/e=206 (M+1).

후처리

  1. customThe progress of the reaction was monitored by TLC and upon completion of the reaction
  2. filtrationthe mixture was filtered under nitrogen atmosphere
  3. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-ac0874e7ff6c46658b2fe821ad1c95e2
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772245B2

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