Potassium Iodide → 4-Chloro-2-iodo-1-nitrobenzene

HRID 50142

반응식

HRID 50142 반응식
[N+:1]([C:4]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:5]=1N)([O-:3])=[O:2].N([O-])=O.[Na+].[I-:16].[K+]>Cl.O>[N+:1]([C:4]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:5]=1[I:16])([O-:3])=[O:2]

참가 물질

6

반응물 3

HCID 4875Potassium IodideHCID 742185-Chloro-2-nitroanilineHCID 23668193Sodium Nitrite

생성물 1

HCID 114261004-Chloro-2-iodo-1-nitrobenzene

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매2회

실험 절차

To a suspension of 2-nitro-5-chloroaniline (5.00 g) in conc. hydrochloric acid (30 ml) under cooling with ice, was added a solution of sodium nitrite (2.10 g) in water (10 ml) dropwise and the mixture was stirred for 30 minutes. Under cooling with ice, to this solution was added a solution of potassium iodide (5.30 g) in water (20 ml) dropwise and the mixture was stirred for 1 hour at room temperature. The solid that appeared was collected by filtration and was dissolved in ethyl acetate and was dried and concentrated to give a crude product of the title compound. It was purified by recrystallization from ethyl acetate-hexane to give the title compound having the following physical data (5.14 g, yellow powder).

후처리

  1. temperatureunder cooling with ice
  2. temperatureUnder cooling with ice, to this solution
  3. stirringthe mixture was stirred for 1 hour at room temperature
  4. filtrationThe solid that appeared was collected by filtration
  5. dissolutionwas dissolved in ethyl acetate
  6. customwas dried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e7ff242b5f244e8b8bfce82155179acc
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710205B2

연결된 노트

불러오는 중…