[NH:1]1[CH:5]([C:6]([OH:8])=[O:7])[CH2:4][CH:3]2[CH2:9][CH2:10][CH2:11][CH:2]12.[OH-].[Na+].[C:14]([C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1)(=[O:16])[CH3:15]>CN(C=O)C>[C:14]([C:17]1[CH:18]=[CH:19][C:20]([S:23]([N:1]2[CH:5]([C:6]([OH:8])=[O:7])[CH2:4][CH:3]3[CH2:9][CH2:10][CH2:11][CH:2]23)(=[O:25])=[O:24])=[CH:21][CH:22]=1)(=[O:16])[CH3:15]1 g of octahydrocyclopenta[b]pyrrole-2-carboxylic acid (6.45 mmol) was dissolved in 20 ml of DMF, after which 3 equivalents of a 3N solution of NaOH (6.45 ml) were added at 0° C. After 10 min, a solution of 1.55 g of 4-acetylbenzenesulfonyl chloride (1.1 equivalents, 7.1 mmol) in 8 ml of DMF was slowly added dropwise; after it had reached RT, the mixture was stirred at 40° C. for a further 6 h and, after that, the solvent was removed under reduced pressure. The crude product was purified chromatographically.
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