Hydrochloric Acid → HCID 59424843, 화합물

HRID 501502

반응식

HRID 501502 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7](F)=[CH:6][C:5]=1[F:11])=[O:3].C([Si](C(C)C)(C(C)C)[S:16][C:17]1[CH:18]=[C:19]([C:23]2([C:29]([NH2:31])=[O:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[CH:20]=[CH:21][CH:22]=1)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.CC(C)([O-])C.[K+].Cl>C(OCC)(=O)C.C1(C)C=CC=CC=1>[C:2]([C:4]1[CH:9]=[CH:8][C:7]([S:16][C:17]2[CH:18]=[C:19]([C:23]3([C:29]([NH2:31])=[O:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:20]=[CH:21][CH:22]=2)=[CH:6][C:5]=1[F:11])(=[O:3])[CH3:1]

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 677702,4-DifluoroacetophenoneHCID 2724141Tetrabutylammonium FluorideHCID 23665647Potassium tert-butoxideHCID 566014104-(3-(triisopropylsilylthio)phenyl)tetrahydro-2H-pyran-4-carboxamide

생성물 1

HCID 59424843HCID 59424843, 화합물

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8857Ethyl Acetate용매

실험 절차

2,4-Difluoroacetophenone (0.40 g, 2.54 mmols), 4-{3-[(triisopropylsilyl)thio]phenyl}-tetra-hydro-2H-pyran-4-carboxamide (1.0 g, 2.54 mmols), tetrabutylammonium fluoride (0.66 g, 2.54 mmols), and potassium tert-butoxide (1.0 M in THF, 2.54 ml, 2.54 mmols) were added to anhydrous toluene (10 ml). The mixture was warmed to 90 degrees Celcius and stirred for 4 hours. After cooling to room temperature, ethyl acetate was added (100 ml) along with 1.0 N HCl (6 ml). The mixture was then stirred for 30 minutes and a beige precipate was collected by suction filtration. The crude product was purified further on silica gel eluting with a 70:30 mixture of methylene chloride and acetone. The appropriate fractions were concentrated to a light brown solid, (0.61 g, 64%).

후처리

  1. temperatureThe mixture was warmed to 90 degrees Celcius
  2. stirringThe mixture was then stirred for 30 minutes
  3. filtrationa beige precipate was collected by suction filtration
  4. customThe crude product was purified further on silica gel eluting with a 70:30 mixture of methylene chloride and acetone
  5. concentrationThe appropriate fractions were concentrated to a light brown solid, (0.61 g, 64%)

출처 및 근거

ORD 기록
ord-5657c0da012f435683a36db2faaed799
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772269B2

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