Hydrochloric Acid → 4-(3,5-Dichloro-phenyl)-6-[(6chloro-pyridin-3-yl)-hydroxy-(3-methyl-3h-imidazol4-yl)-methyl]-1h-quinolin-2-one

HRID 50158노트

반응식

HRID 50158 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]([C:27]4[CH:28]=[N:29][C:30]([Cl:33])=[CH:31][CH:32]=4)([C:21]4[N:22]([CH3:26])[CH:23]=[N:24][CH:25]=4)[OH:20])[CH:17]=3)[N:12]=[C:11]([O:34]C)[CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]([C:27]4[CH:28]=[N:29][C:30]([Cl:33])=[CH:31][CH:32]=4)([OH:20])[C:21]4[N:22]([CH3:26])[CH:23]=[N:24][CH:25]=4)[CH:17]=3)[NH:12][C:11](=[O:34])[CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22465439[4-(3,5-dichloro-phenyl)-2-methoxy-quinolin-6-yl]-(6-chloro-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanol

생성물 1

HCID 224654294-(3,5-Dichloro-phenyl)-6-[(6chloro-pyridin-3-yl)-hydroxy-(3-methyl-3h-imidazol4-yl)-methyl]-1h-quinolin-2-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Following the same procedure as described in example 1F, [4-(3,5-dichloro-phenyl)-2-methoxy-quinolin-6-yl]-(6-chloro-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanol (886 mg, 1.68 mmol) was treated with HCl in aqueous THF to yield the title compound of 16D. It was directly used for the next reaction without further purification.

출처 및 근거

ORD 기록
ord-abe183fdc4214b0c88e90d171ffa3632
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710209B2

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