Hydrochloric Acid → HCID 178422984, 화합물
반응식
O[NH:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[OH:11].C(N(CC)CC)C.S(Cl)(Cl)=O.Cl>O1CCCC1.O>[CH3:10][C:7]1[CH:8]=[CH:9][C:4]2[C:3]([OH:12])=[N:2][O:11][C:5]=2[CH:6]=1참가 물질
7
실험 절차
44.0 g of N,2-dihydroxy-4-methylbenzamide was suspended in 880 mL of tetrahydrofuran, to which 147 mL of triethylamine was added dropwise at room temperature and then 28.7 mL of thionyl chloride was added dropwise at 5 to 10° C. successively, and this mixture was stirred for one hour at room temperature. The reaction mixture was added to water, and adjusted to pH 1 with 12M hydrochloric acid, and then resultant precipitate was filtered out thereof. The resultant solid was washed with water to yield 35.2 g of 6-methyl-1,2-benzisoxazol-3-ol as light yellow solid.
후처리
- additionwas added dropwise at room temperature
- filtrationresultant precipitate was filtered out thereof
- washThe resultant solid was washed with water
출처 및 근거
- ORD 기록
- ord-0dbf453ba57d4c57bee8b19a1d6b81b0
- 출처 데이터셋
- uspto-grants-2010_08
- 특허 번호
- US07772285B2
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