Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride

HRID 501830

반응식

HRID 501830 반응식
C([O:3][C:4](=[O:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=1)C.[ClH:18]>>[ClH:18].[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 309738Ethyl 2-(4-acetamidophenoxy)acetate

생성물 1

HCID 668114882-(4-Aminophenoxy)acetic acid hydrochloride수율 77.6%

반응 조건

온도
10 °C

실험 절차

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2(250 g, 77.6%) as a wheat colored powder.

후처리

  1. distillationExcess concentrated Hydrochloric acid was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

출처 및 근거

ORD 기록
ord-88965aaa5e764a9a987fed00cee01d87
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772352B2

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