6-(4-Nitrophenoxy)-hexanoic acid methyl ester → 6-(4-Nitrophenoxy)hexanoic acid

HRID 501852

반응식

HRID 501852 반응식
C[O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1>Cl>[N+:16]([C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:19])=[O:2])=[CH:15][CH:14]=1)([O-:18])=[O:17]

참가 물질

3

반응물 1

HCID 146502956-(4-Nitrophenoxy)-hexanoic acid methyl ester

생성물 1

HCID 223889056-(4-Nitrophenoxy)hexanoic acid수율 80.2%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

6-(4-nitrophenoxy)-hexanoic acid methyl ester 21 (125 g, 468.16 mmol) was refluxed in conc. HCl (1250 ml) for 16 hours. The reaction mixture was cooled to room temp., filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 35 (95 g, 80.2%) as a white powder with an m.p. between 104-107° C.

후처리

  1. temperatureThe reaction mixture was cooled to room temp.
  2. filtrationfiltered
  3. customdried
  4. customrecrystallised from a mixture of ethyl acetate:hexane (1:6)

출처 및 근거

ORD 기록
ord-d1fe644fb5cc4660bc8da73d040dcbd9
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772352B2

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