Sodium Hydroxide → 2-[N-(4-amidinophenyl)aminomethyl]benzothiazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(hydroxycarbonylmethyl) amide dihydrochloride
반응식
[ClH:1].Cl.[N:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]([CH2:32][C:33]([O:35]CC)=[O:34])[C:10]([C:12]1[CH:13]=[CH:14][C:15]2[S:19][C:18]([CH2:20][NH:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[NH:30])[NH2:29])=[CH:24][CH:23]=3)=[N:17][C:16]=2[CH:31]=1)=[O:11].[OH-].[Na+]>>[ClH:1].[ClH:1].[N:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]([CH2:32][C:33]([OH:35])=[O:34])[C:10]([C:12]1[CH:13]=[CH:14][C:15]2[S:19][C:18]([CH2:20][NH:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[NH:29])[NH2:30])=[CH:24][CH:23]=3)=[N:17][C:16]=2[CH:31]=1)=[O:11]참가 물질
3
반응물 2
생성물 1
실험 절차
Prepared analogously to Example 10 from 2-[N-(4-amidinophenyl)aminomethyl]benzothiazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(ethoxycarbonylmethyl)amide dihydrochloride and sodium hydroxide solution. Yield: 90% of theory, C23H20N6O3S (460.52); EKA mass spectrum: (M+H)+=461; (M+Na)+=483; (M+2Na)++=253.