Sodium Hydroxide → 3-Cyclopropyl-5-methoxybenzoic acid

HRID 502451노트

반응식

HRID 502451 반응식
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[C:6]([CH:12]2[CH2:14][CH2:13]2)[CH:5]=1.[OH-].[Na+]>C1COCC1.C(O)C>[CH:12]1([C:6]2[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH3:11])[CH:7]=2)[C:3]([OH:15])=[O:2])[CH2:13][CH2:14]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 68459588HCID 68459588, 화합물

생성물 1

HCID 684548573-Cyclopropyl-5-methoxybenzoic acid수율 98.2%

시약·촉매·용매 1

HCID 21873804Tetrahydrofuran ethanol용매

실험 절차

The above prepared 3-cyclopropyl-5-methoxy-benzoic acid methyl ester (0.221 g, 1.07 mmol) was dissolved in 3.6 ml of THF/ethanol=1/1 and treated with 1.79 ml of aq. NaOH (3M, 5 eq.). The mixture was stirred for 1.5 h at ambient temperature and was then poured onto crashed ice/AcOEt/HCl dil.; the organic layer was washed with water, dried over sodium sulfate, and evaporated to dryness to leave 0.202 g of the title compound as white solid.

후처리

  1. additionwas then poured
  2. washthe organic layer was washed with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-edf3cd432fb348e48c8a147ae9c641a4
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772253B2

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