Water → 3-(Benzodioxol-5-yl)propionic acid

HRID 5025

반응식

HRID 5025 반응식
[CH2:1]1[O:14][C:13]2[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][C:3]=2[O:2]1.O.[H][H]>[OH-].[Na+].[Pd]>[CH2:1]1[O:14][C:13]2[CH:12]=[CH:11][C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[CH:4][C:3]=2[O:2]1

참가 물질

6

반응물 3

HCID 962WaterHCID 169173-(1,3-Benzodioxol-5-yl)prop-2-enoic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 648103-(Benzodioxol-5-yl)propionic acid수율 97%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 14798Sodium Hydroxide용매

실험 절차

To a solution of 10.0 g of 3,4-methylenedioxycinnamic acid dissolved in 130 ml of 10% NaOH and 80 ml of distilled water was added 1.0 g of 5% Pd-C. This mixture was reacted at 40 psi until the consumption of hydrogen gas was ceased and then filtered through a Celite layer. The filtrate was acidified with concentrated hydrochloric acid, allowed to be cooled and filtered to give solids. The obtained solids were washed twice with 100 ml of cold water and dried to provide 9.8 g(yield 97%) of 3-(3,4-methylenedioxyphenyl) propanoic acid, having the characteristics of: NMR(CDCl3, 200 MHz) δ2.62(t, J=7 Hz, 2H, CH2), 2.88(t, J=7 Hz, 2H, CH2N), 5.93(s, 2H, CH2O2), 6.63-6.76(s, 3H, ArH).

후처리

  1. filtrationfiltered through a Celite layer
  2. temperatureto be cooled
  3. filtrationfiltered
  4. customto give solids
  5. washThe obtained solids were washed twice with 100 ml of cold water
  6. customdried

출처 및 근거

ORD 기록
ord-cba18c7783e64b07b2d8f20d24a2f6f6
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242944

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