Trimethyl borate → [4-(Difluoromethyl)phenyl]boronic acid

HRID 502857노트

반응식

HRID 502857 반응식
[F:1][CH:2]([F:10])[C:3]1[CH:8]=[CH:7][C:6](I)=[CH:5][CH:4]=1.C([Mg]Cl)(C)C.[B:16](OC)([O:19]C)[O:17]C>>[F:1][CH:2]([F:10])[C:3]1[CH:8]=[CH:7][C:6]([B:16]([OH:19])[OH:17])=[CH:5][CH:4]=1

참가 물질

4

반응물 3

HCID 8470Trimethyl borateHCID 463117371-(Difluoromethyl)-4-iodobenzeneHCID 178418918HCID 178418918, 화합물

생성물 1

HCID 20777176[4-(Difluoromethyl)phenyl]boronic acid

실험 절차

In a departure from the procedure described above the compound is prepared from 4-difluoromethyl-1-iodo-benzene (prepared from 4-iodobenzaldehyde using diethylaminosulfurtrifluoride (DAST) in dichloromethane) using iPrMgCl to generate the arylmetal compound and trapping this intermediate with trimethyl borate.

출처 및 근거

ORD 기록
ord-578649c648b84fa593df4981d55ea478
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776830B2

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