Ethanol → 2-Methyl-2-(2-thienyl)propanohydrazide

HRID 502947노트

반응식

HRID 502947 반응식
O.[NH2:2][NH2:3].C(O)C.[CH3:7][C:8]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)([CH3:14])[C:9](OCC)=[O:10].C(OCC)(=O)C>O>[CH3:7][C:8]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)([CH3:14])[C:9]([NH:2][NH2:3])=[O:10]

참가 물질

6

반응물 4

HCID 702EthanolHCID 8857Ethyl AcetateHCID 24654Hydrazine hydrate (1:1)HCID 21099804Ethyl 2-methyl-2-(thiophen-2-yl)propanoate

생성물 1

HCID 684672282-Methyl-2-(2-thienyl)propanohydrazide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

Hydrazine monohydrate (2.6 ml) was added to an ethanol (10 ml) solution of ethyl 2-methyl-2-(2-thienyl)propanoate (530 mg), followed by stirring at 70° C. for 48 hours. After the reaction solution and ethyl acetate were added to water, the organic layer was separated. Furthermore, the organic layer washed with saturated brine and, after drying over anhydrous sodium sulfate and filtration, the solvent was removed by evaporation under reduced pressure to obtain 447 mg of 2-methyl-2-(2-thienyl)propanohydrazide (colorless oil).

후처리

  1. customthe organic layer was separated
  2. washFurthermore, the organic layer washed with saturated brine
  3. dry with materialafter drying over anhydrous sodium sulfate and filtration
  4. customthe solvent was removed by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-f2d9600b8fef4ae08d1d12d2e70eb7b7
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776897B2

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