Toluene → Methyl 3-[(cyclopropylamino)carbonyl]benzoate

HRID 502964노트

반응식

HRID 502964 반응식
[C:1]1([CH3:7])C=CC=C[CH:2]=1.[CH3:8][O:9][C:10]([C:12]1[CH:13]=[C:14]([C:18]([OH:20])=O)[CH:15]=[CH:16][CH:17]=1)=[O:11].S(Cl)(Cl)=O.C[N:26](C=O)C>C(Cl)(Cl)Cl>[CH:1]1([NH:26][C:18]([C:14]2[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=2)[C:10]([O:9][CH3:8])=[O:11])=[O:20])[CH2:2][CH2:7]1

참가 물질

6

반응물 4

HCID 1140TolueneHCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 6018803-(Methoxycarbonyl)benzoic acid

생성물 1

HCID 47231565Methyl 3-[(cyclopropylamino)carbonyl]benzoate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Toluene solution of 3-(Methoxycarbonyl)benzenecarboxylic acid, thionyl chloride and DMF (a catalytic amount) were heated under stirring. The reaction solution was dissolved in chloroform after evaporation under reduced pressure. After cyclopropylamine and triethylamine were added thereto and the whole was stirred at room temperature to obtain methyl 3-[(cyclopropylamino)carbonyl]benzoate.

후처리

  1. customafter evaporation under reduced pressure
  2. additionAfter cyclopropylamine and triethylamine were added
  3. stirringthe whole was stirred at room temperature

출처 및 근거

ORD 기록
ord-7970b8c847374f64b42bda5eaa1518c8
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776897B2

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