Hydrochloric Acid → HCID 24861656, 화합물

HRID 503656노트

반응식

HRID 503656 반응식
[OH:1][CH:2]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([OH:38])[CH:33]=1)[C:3]([NH:5][NH:6][C:7](=[O:31])[C:8]1[C:13]([O:14]CC2C=CC=CC=2)=[CH:12][C:11]([O:22]CC2C=CC=CC=2)=[CH:10][C:9]=1[Cl:30])=[O:4].Cl>C1COCC1>[OH:1][CH:2]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([OH:38])[CH:33]=1)[C:3]([NH:5][NH:6][C:7](=[O:31])[C:8]1[C:13]([OH:14])=[CH:12][C:11]([OH:22])=[CH:10][C:9]=1[Cl:30])=[O:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57857230HCID 57857230, 화합물

생성물 1

HCID 24861656HCID 24861656, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

720 mg of N′-[2-hydroxy-2-(3-hydroxyphenyl)acetyl]-2-chloro-4,6-dibenzyloxybenzohydrazide in 20 ml of THF+0.2 ml of 32% HCl are hydrogenated with the calculated amount of H2 using 360 mg of PdoC. The hydrogenation solution is evaporated and chromatographed on silica gel. The uniform fractions are combined, evaporated and recrystallised from EtOAc. Yield 310 mg (65%) of “A15”, m.p. 230-231°.

후처리

  1. customThe hydrogenation solution is evaporated
  2. customchromatographed on silica gel
  3. customevaporated
  4. customrecrystallised from EtOAc

출처 및 근거

ORD 기록
ord-e64e2c6f095647f6b5861e9b05bec565
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776920B2

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