Pyridine → N-(4-methylpyridin-3-yl)acetamide

To solution of 3-amino-4-methylpyridine (540.2 Mg, 5.0 Mmol, 1 equiv) in dichloromethane (20 mL) was added pyridine (0.8 mL, 10.0 Mmol, 2 equiv) and acetic anhydride (0.57 mL, 6.0 Mmol, 1.2 equiv). The resultant solution was stirred at room temperature for 16 h and concentrated in vacuo to provide a crude residue. The residue was diluted with dichloromethane (200 mL), and washed with saturated sodium bicarbonate aqueous solution (50 mL) and brine (50 mL). The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo to yield 3-acetylamino-4-methylpyridine (400.2 Mg) as yellow solid which was used without further purification.

1. concentrationconcentrated in vacuo
2. customto provide a crude residue
3. washwashed with saturated sodium bicarbonate aqueous solution (50 mL) and brine (50 mL)
4. customThe organic layer was separated
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo

ORD 기록

ord-04cbf0a2d186487fbf29d8355421e0e3

출처 데이터셋

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07777035B2