Triethylamine → Ethyl [(phenoxycarbonyl)oxy]acetate

HRID 504064

반응식

HRID 504064 반응식
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:3].[C:11]([O:15][CH2:16][CH3:17])(=[O:14])[CH2:12][OH:13].C(N(CC)CC)C>C1(C)C=CC=CC=1>[O:4]([C:2]([O:13][CH2:12][C:11]([O:15][CH2:16][CH3:17])=[O:14])=[O:3])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12184Ethyl GlycolateHCID 15891Phenyl chloroformate

생성물 1

HCID 12094709Ethyl [(phenoxycarbonyl)oxy]acetate수율 92.8%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

13.5 ml (105.6 mmol) of phenyl chloroformate are added, dropwise, at ambient temperature to a solution of 10 g (96.15 mmol) of ethyl glycolate and 27 ml (192.3 mmol) of triethylamine in 20 ml of toluene and the mixture is stirred at ambient temperature for 2 h. The salt formed is separated and the filtrate is concentrated under reduced pressure to obtain 20 g of oily product, which are used without modification in the following step.

후처리

  1. customThe salt formed
  2. customis separated
  3. concentrationthe filtrate is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-bbd48102c7484f56a47adf9e6ebbdf53
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07777057B2

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