Water → 2-Bromo-4-thienyl-methoxyethyl methacrylate

HRID 5050

반응식

HRID 5050 반응식
[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][O:8][CH2:9]CO)[CH:6]=1.N1C=CC=C[CH:13]=1.C(#N)C.[C:21](Cl)(=[O:25])[C:22]([CH3:24])=[CH2:23].[OH2:27]>C(OCC)(=O)C>[C:21]([O:25][CH2:13][CH:7]([C:5]1[CH:6]=[C:2]([Br:1])[S:3][CH:4]=1)[O:8][CH3:9])(=[O:27])[C:22]([CH3:24])=[CH2:23]

참가 물질

7

반응물 5

HCID 962WaterHCID 1049PyridineHCID 6342AcetonitrileHCID 13528Methacryloyl chlorideHCID 197977502-Bromo-4-2-hydroxyethoxymethylthiophene

생성물 1

HCID 570171242-Bromo-4-thienyl-methoxyethyl methacrylate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

While stirring a mixture of 0.1 mol of 2-bromo-4-2-hydroxyethoxymethylthiophene, 0.1 mol of pyridine, and 100 ml of acetonitrile at a temperature of lower than 10° C., 0.1 mol of methacryloyl chloride was added dropwise to the mixture over a period of 30 minutes. After stirring the mixture for one hour, 200 ml of ethyl acetate and 200 ml of water were added to the mixture. The ethyl acetate layer was extracted, concentrated, and purified by column chromatography to provide 22.1 g of 2-bromo-4-thienyl-methoxyethyl methacrylate (5-A).

후처리

  1. stirringAfter stirring the mixture for one hour
  2. extractionThe ethyl acetate layer was extracted
  3. concentrationconcentrated
  4. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-65ea4057d75b4366aba54ef2265871f0
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05243004

연결된 노트

불러오는 중…