Lithium hydroxide, monohydrate → Lithium 2-amino-6-chloronicotinate

HRID 505068노트

반응식

HRID 505068 반응식
O[Li:2].O.[NH2:4][C:5]1[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8]>O.CO>[NH2:4][C:5]1[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:6]=1[C:7]([O-:9])=[O:8].[Li+:2]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 57415887Methyl 2-amino-6-chloronicotinate

생성물 1

HCID 59772570Lithium 2-amino-6-chloronicotinate수율 114.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

A solution of LiOH.H2O (1.38 g, 33 mmol) in water (33 mL) was added in one portion to a suspension of methyl 2-amino-6-chloronicotinate (6.08 g, 27 mmol) in MeOH (110 mL). The reaction mixture was stirred at 70° C. for 24 hours, and gradually became homogeneous. The solvents were removed under reduced pressure, and after the resulting white solid was dried under vacuum (<1 mmHg) to constant weight, 5.51 g (95%) of lithium 2-amino-6-chloronicotinate was obtained.

후처리

  1. customThe solvents were removed under reduced pressure
  2. customafter the resulting white solid was dried under vacuum (<1 mmHg) to constant weight

출처 및 근거

ORD 기록
ord-abc11101d7ea4bea821c01a30c9631ae
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781437B2

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