Methyl iodide → HCID 178503328, 화합물

HRID 505328노트

반응식

HRID 505328 반응식
[CH3:1][I:2].[Br:3][C:4]1[CH:5]=[C:6]([Cl:16])[CH:7]=[C:8]2[C:13]=1[NH:12][C:11](=[S:14])[NH:10][CH:9]2[CH3:15]>CC(C)=O>[IH:2].[Br:3][C:4]1[CH:5]=[C:6]([Cl:16])[CH:7]=[C:8]2[C:13]=1[N:12]=[C:11]([S:14][CH3:1])[NH:10][CH:9]2[CH3:15]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 866089558-Bromo-6-chloro-3,4-dihydro-4-methyl-2(1H)-quinazolinethione

생성물 1

HCID 178503328HCID 178503328, 화합물수율 58.1%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Methyl iodide (0.51 ml, 8.23 mmol) was added to a suspension of 8-bromo-6-chloro-4-methyl-3,4-dihydro-1H-quinazoline-2-thione (800 mg, 2.74 mmol) in acetone (8 ml). The mixture was stirred for 3 hours (r.t.), and the title compound (690 mg, 58%) was isolated from the reaction mixture by filtration.

출처 및 근거

ORD 기록
ord-c1c2627ee6814906b551889d526ef8a0
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781441B2

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