Water → 6-Methoxy-5-methyl-2-nitro-3-pyridinamine

HRID 505381노트

반응식

HRID 505381 반응식
[CH3:1][O:2][C:3]1[N:8]=[C:7]([N+:9]([O-:11])=[O:10])[C:6]([NH:12]C(=O)C)=[CH:5][C:4]=1[CH3:16].[OH-].[Na+].O>CO>[CH3:1][O:2][C:3]1[N:8]=[C:7]([N+:9]([O-:11])=[O:10])[C:6]([NH2:12])=[CH:5][C:4]=1[CH3:16]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 59429836N-(6-methoxy-5-methyl-2-nitro-3-pyridinyl)acetamide

생성물 1

HCID 594298446-Methoxy-5-methyl-2-nitro-3-pyridinamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The crude product (1.93 g) of N-(6-methoxy-5-methyl-2-nitro-3-pyridinyl) acetamide was dissolved in methanol (36 ml), 5N sodium hydroxide solution (6 ml) was added, and the reaction mixture was stirred for 15 minutes at room temperature. After water was added to the reaction solution, it was extracted with ethyl acetate and dried over magnesium sulfate, and the solvent was evaporated, thereby yielding the title compound (1.06 g, 5.79 mmol) as a yellow solid.

후처리

  1. extractionwas extracted with ethyl acetate
  2. dry with materialdried over magnesium sulfate
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-7e8cb2b8bc3f4da4a4c933dcf9bf1f6b
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781452B2

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