홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropylethylamine → N-[2-Amino-5-(4-chloro-phenyl)-pyridin-3-yl]3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionamide

HRID 505424
노트
인쇄 미리보기

반응식

HRID 505424 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:5]=[C:4]([CH2:28][CH2:29][C:30]([OH:32])=O)[CH:3]=1.[NH2:33][C:34]1[C:39]([NH2:40])=[CH:38][C:37]([C:41]2[CH:46]=[CH:45][C:44]([Cl:47])=[CH:43][CH:42]=2)=[CH:36][N:35]=1.C(N(C(C)C)CC)(C)C>N1C=CC=CC=1>[NH2:33][C:34]1[C:39]([NH:40][C:30](=[O:32])[CH2:29][CH2:28][C:4]2[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([NH:8][C:9]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:5]=2)=[CH:38][C:37]([C:41]2[CH:42]=[CH:43][C:44]([Cl:47])=[CH:45][CH:46]=2)=[CH:36][N:35]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 684615903-[4-Methyl-6-(trityl-amino)-pyridin-2-yl]propionic acid2회HCID 684635682,3-Diamino-5-(4-chlorophenyl)-pyridine2회

생성물 1

HCID 68465037N-[2-Amino-5-(4-chloro-phenyl)-pyridin-3-yl]3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionamide수율 91.4%

시약·촉매·용매 1

HCID 1049
Pyridine
용매

반응 조건

온도
40 °C

실험 절차

300 mg of 3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionic acid (compound C4) and 156 mg of 2,3-diamino-5-(4-chloro-phenyl)-pyridine (compound F4) are dissolved in 13 ml of pyridine and sequentially treated with 280 mg of O-[(ethoxycarbonyl)canomethylene-amino]—N,N,N′,N′-tetramethyl-uronium tetrafluoroborate and 153 μl of diisopropylethyl amine. The reaction mixture is warmed to 40° C. for 120 h. Purification of the crude product by chromatography on silica gel (eluent: dichloromethane/methanol 8:1) afforded 405 mg of the title compound as an oil. ESI-MS: 624.1/626.1 (MH+, 100%/38%). TLC: Rf=0.32 (dichloromethane/methanol 8:1).

후처리

  1. customPurification of the crude product by chromatography on silica gel (eluent: dichloromethane/methanol 8:1)

출처 및 근거

ORD 기록
ord-ff175323f16d41c3a7aebad482edc819
출처 데이터셋
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07781453B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트