Benzophenone imine → [(Diphenylmethylene)amino]acetonitrile

HRID 505650

반응식

HRID 505650 반응식
[C:1](=[NH:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:16][CH2:17][C:18]#N>ClCCl>[C:1](=[N:14][CH2:18][C:17]#[N:16])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 136809Benzophenone imineHCID 11491918Aminoacetonitrile hydrochloride

생성물 1

HCID 612957[(Diphenylmethylene)amino]acetonitrile수율 157.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of benzophenone imine (25 g, 0.138 mol, Aldrich) and aminoacetonitrile hydrochloride (25 g, 0.270 mol, Lancaster) in dichloromethane (1000 mL) was stirred in a 2 L Erlenmeyer flask under nitrogen at room temperature for five days. The reaction mixture was filtered to remove the precipitated ammonium chloride and the filtrate was evaporated to dryness in vacuo. The resulting residue was dissolved in ether (400 mL) and washed with water (200 mL) and brine. After drying over magnesium sulfate, the solution was evaporated to give (benzhydrylideneamino)-acetonitrile (47.89 g).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customto remove the precipitated ammonium chloride
  3. customthe filtrate was evaporated to dryness in vacuo
  4. dissolutionThe resulting residue was dissolved in ether (400 mL)
  5. washwashed with water (200 mL) and brine
  6. dry with materialAfter drying over magnesium sulfate
  7. customthe solution was evaporated

출처 및 근거

ORD 기록
ord-3053e97a38aa494caaeb83b88158650e
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781487B2

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