Tetramethoxypropane → 2-(5-Bromopyridin-3-yl)pyrimidine
반응식
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[C:8]([Br:10])[CH:9]=1)(=[NH:3])[NH2:2].CO[CH:13](OC)[CH2:14][CH:15](OC)OC>CN(C=O)C>[Br:10][C:8]1[CH:7]=[N:6][CH:5]=[C:4]([C:1]2[N:2]=[CH:15][CH:14]=[CH:13][N:3]=2)[CH:9]=1참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
A mixture of the product of Step B (4.86 g, 20.5 mmol) and 1,1,3,3-tetramethoxypropane (6.59 mL, 40 mmol) in DMF (25 mL) was warmed to 90° C. under N2. After 18 h, the reaction mixture was allowed to cool to 25° C., concentrated in vacuo. Purification of the residue by flash chromatography (EtOAc) afforded the title compound (1.05 g, 22%) as a white solid. MS 237 (M+H)+
후처리
- temperatureto cool to 25° C.
- concentrationconcentrated in vacuo
- customPurification of the residue by flash chromatography (EtOAc)
출처 및 근거
- ORD 기록
- ord-7965c9f22cdb4c98b630f5880c75baee
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713455B2
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