Methanol → 9-Ethyl-9H-carbazole-3-carboxylic acid

HRID 50609

반응식

HRID 50609 반응식
[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12]([CH:16]=[O:17])=[CH:11][C:10]=2[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH3:2].[Mn]([O-])(=O)(=O)=[O:19].[K+].CO>CC(C)=O>[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12]([C:16]([OH:19])=[O:17])=[CH:11][C:10]=2[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH3:2]

참가 물질

5

반응물 3

HCID 887MethanolHCID 820559-ethyl-9H-carbazole-3-carbaldehydeHCID 516875Potassium Permanganate

생성물 1

HCID 49128699-Ethyl-9H-carbazole-3-carboxylic acid수율 61.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

50 g of N-ethylcarbazole-3-carboxaldehyde was dissolved in 1 L of acetone, and the solution was added with 70.6 g of potassium permanganate under ice cooling, stirred for 3 hours, then added with 100 mL of methanol and filtered. The filtrate was evaporated under reduced pressure, and the residue was dissolved in aqueous sodium hydrogencarbonate. Then, the solution was made acidic by adding concentrated hydrochloric acid, and the deposited precipitates were collected to obtain 33 g of N-ethylcarbazole-3-carboxylic acid.

후처리

  1. filtrationfiltered
  2. customThe filtrate was evaporated under reduced pressure
  3. dissolutionthe residue was dissolved in aqueous sodium hydrogencarbonate
  4. additionby adding concentrated hydrochloric acid
  5. customthe deposited precipitates
  6. customwere collected

출처 및 근거

ORD 기록
ord-cd235a0093da40bfaf22543d6aff285a
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713473B1

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