Iodine → HCID 178510339, 화합물

HRID 506172노트

반응식

HRID 506172 반응식
[OH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][CH:3]=1.[I:10]I.[OH-].[Na+]>O>[OH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][C:3]=1[I:10]

참가 물질

5

반응물 3

HCID 807IodineHCID 14798Sodium HydroxideHCID 178510337HCID 178510337, 화합물

생성물 1

HCID 178510339HCID 178510339, 화합물수율 61.3%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
85 °C

실험 절차

A mixture of 4-hydroxynicotinonitrile (45.7 g, 381 mmol), iodine (96.6 g, 381 mmol) and NaOH (19.8 g, 825 mmol) in water (600 mL) was heated at 85° C. overnight, cooled to r.t. and diluted with water. The precipitate was collected by filtration and washed with water to give 57.5 g (61%) of 4-hydroxy-5-iodonicotinonitrile as a tan solid. Mp>245° C.

후처리

  1. temperaturecooled to r.t.
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water

출처 및 근거

ORD 기록
ord-a88d4654205b49ecac2b716b56ed3020
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781591B2

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