Sodium borohydride → 1-(5-Bromo-2-chlorophenyl)ethanol
반응식
[BH4-].[Na+].[Br:3][C:4]1[CH:5]=[CH:6][C:7]([Cl:13])=[C:8]([C:10](=[O:12])[CH3:11])[CH:9]=1>CO>[Br:3][C:4]1[CH:5]=[CH:6][C:7]([Cl:13])=[C:8]([CH:10]([OH:12])[CH3:11])[CH:9]=1참가 물질
4
실험 절차
Sodium borohydride (1.182 g, 51.4 mmol) was added to a stirred solution of 1-(5-bromo-2-chlorophenyl)ethanone (10 g, 42.8 mmol) in methanol at 0° C. The resulting bubbling white mixture was allowed to warm to ambient temperature and stirred for 2 h. The reaction mixture was quenched with acetone (50 mL) and concentrated by rotary evaporation. The residue was partitioned between ethyl acetate and water. The organic phase was dried and concentrated to yield the title compound (10 g, 99% yield) as a white solid: 1H NMR (CDCl3) δ 7.75 (d, 1H), 7.32 (m, 1H), 7.19 (m, 1H), 5.23 (q, 1H), 1.95 (d, 1H), 1.48 (d, 3H).
후처리
- customThe resulting bubbling white mixture
- customThe reaction mixture was quenched with acetone (50 mL)
- concentrationconcentrated by rotary evaporation
- customThe residue was partitioned between ethyl acetate and water
- customThe organic phase was dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-fa53a66b553842db98aa096d79ab48cd
- 출처 데이터셋
- uspto-grants-2010_08
- 특허 번호
- US07786044B2
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