Sodium Hydroxide → HCID 178503121, 화합물

HRID 506591

반응식

HRID 506591 반응식
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[CH3:12][S:13][C:14]1[CH:22]=[CH:21][C:17]([C:18](O)=O)=[CH:16][CH:15]=1.[OH-].[Na+]>O>[CH3:12][S:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]2[NH:1][C:2]3=[N:3][CH:4]=[C:5]([N+:9]([O-:11])=[O:10])[CH:6]=[C:7]3[N:8]=2)=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 832304-(Methylthio)benzoic acidHCID 34801515-Nitropyridine-2,3-diamine

생성물 1

HCID 178503121HCID 178503121, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1.0 g 2,3-diamino-5-nitropyridine and 1.125 g 4-methylsulfanylbenzoic acid in 20 ml polyphosphoric acid were heated to 160° C. with stirring for 15 hrs. The mixture was cooled and poured into water. The pH was adjusted to 4-5 by addition of sodium hydroxide and the precipitate collected by filtration. The filtration residue was stirred in 50 ml pyridine at 60° C., cooled and insoluble components removed by filtration. The filtrate was evaporated and the residue used without further purification in the next steps.

후처리

  1. temperatureThe mixture was cooled
  2. filtrationthe precipitate collected by filtration
  3. stirringThe filtration residue was stirred in 50 ml pyridine at 60° C.
  4. temperaturecooled
  5. custominsoluble components removed by filtration
  6. customThe filtrate was evaporated
  7. customthe residue used without further purification in the next steps

출처 및 근거

ORD 기록
ord-8474e7643ba740139fd5909dc95249b9
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786113B2

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