Bromine → 5-Bromo-4-isopropylthiazol-2-amine

HRID 506624

반응식

HRID 506624 반응식
[CH:1]([C:4]1[N:5]=[C:6]([NH2:9])[S:7][CH:8]=1)([CH3:3])[CH3:2].[Br:10]Br.C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[Br:10][C:8]1[S:7][C:6]([NH2:9])=[N:5][C:4]=1[CH:1]([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 70640774-(Propan-2-yl)-1,3-thiazol-2-amine

생성물 1

HCID 534881395-Bromo-4-isopropylthiazol-2-amine

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

A solution of 4-isopropyl-thiazol-2-ylamine (2.0 g, 14 mmol) in 30 mL CHCl3 was added dropwise to a stirring solution of bromine ((2.697 g, 17 mmol) in 15 mL CHCl3. The reaction mixture was stirred for 60 hours at room temperature. The reaction mixture was poured into saturated aqueous NaHCO3, and extracted with methylene chloride. The combined organic extracts were washed with saturated aqueous NaHCO3 and brine, dried (MgSO4), filtered and concentrated under reduced pressure to give 2.05 g of 5-bromo-4-isopropyl-thiazol-2-ylamine as an oil.

후처리

  1. extractionextracted with methylene chloride
  2. washThe combined organic extracts were washed with saturated aqueous NaHCO3 and brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8ce79d5f437e49689190bcb2f29b2e24
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786110B2

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