Methyl iodide → HCID 46868293, 화합물

HRID 506782노트

반응식

HRID 506782 반응식
[OH-].[K+].[CH3:3]I.[Cl:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]2[N:12]([S:28]([C:31]3[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][CH:32]=3)(=[O:30])=[O:29])[C:13]([C:15]3[C:19]4=[N:20][C:21]([O:26][CH3:27])=[C:22]([O:24][CH3:25])[CH:23]=[C:18]4[NH:17][CH:16]=3)=[CH:14][C:7]=12>CN(C=O)C.CCOC(C)=O>[Cl:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]2[N:12]([S:28]([C:31]3[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][CH:32]=3)(=[O:29])=[O:30])[C:13]([C:15]3[C:19]4=[N:20][C:21]([O:26][CH3:27])=[C:22]([O:24][CH3:25])[CH:23]=[C:18]4[N:17]([CH3:3])[CH:16]=3)=[CH:14][C:7]=12

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 68467297HCID 68467297, 화합물

생성물 1

HCID 46868293HCID 46868293, 화합물수율 104.3%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

Add KOH (5.0 equiv., 21.6 mg) then MeI (5.0 equiv., 55.0 mg, 24 μL) to bisazaindole 28 (37.3 mg, 0.0772 mmol) stirred in DMF (5.0 mL) at 0° C., and stir the reaction medium at for 1.5 h. Then allow the reaction medium to return to room temperature, dilute it with EtOAc, wash it with saturated NaHCO3, dry (MgSO4) and concentrate, to obtain 29 (40 mg, 100%) as an amorphous solid: TLC (EtOAc at 40%/heptane) Rf=0.10.

후처리

  1. customto return to room temperature
  2. washwash it with saturated NaHCO3
  3. dry with materialdry (MgSO4)
  4. concentrationconcentrate

출처 및 근거

ORD 기록
ord-aa18d4ddaeb34ad9988aa1b885db20d6
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786114B2

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