Hydrochloric Acid → N-Methyl-N-(piperidin-4-yl)acetamide

HRID 506858노트

반응식

HRID 506858 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:16](=[O:18])[CH3:17])[CH3:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCOC(C)=O>[CH3:15][N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:16](=[O:18])[CH3:17]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22061331tert-Butyl 4-[acetyl(methyl)amino]piperidine-1-carboxylate

생성물 1

HCID 21468403N-Methyl-N-(piperidin-4-yl)acetamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 4-(acetyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (525 mg, 2.05 mmol) in AcOEt (5 ml) was added HCl 3N (4 ml). The reaction mixture was stirred at RT for 16 hrs. Solvent were removed under reduced pressure to gine the expected N-methyl-N-piperidin-4-yl-acetamide as its hydrochloride salt (395 mg, quant.).

후처리

  1. customSolvent were removed under reduced pressure

출처 및 근거

ORD 기록
ord-0dd63d0f2e3c4e5e9183e378ca92637d
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786121B2

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