Bromine → N-[4-(2-BROMOACETYL)-3-FLUOROPHENYL]acetamide

HRID 507407노트

반응식

HRID 507407 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=1[F:14])(=[O:3])[CH3:2].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=1[F:14])=[O:3]

참가 물질

4

반응물 2

HCID 24408BromineHCID 14621109N-(4-Acetyl-3-fluorophenyl)acetamide

생성물 1

HCID 86346474N-[4-(2-BROMOACETYL)-3-FLUOROPHENYL]acetamide수율 82.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

N-(4-Acetyl-3-fluoro-phenyl)-acetamide (10.2 g, 51.2 mmol) is dissolved in 50 mL chloroform. At room temperature bromine (1.98 mL, 38.4 mmol) is added drop wise. The reaction mixture is stirred at room temperature for 1.5 hours. Subsequently the precipitated product is filtered off, washed first with chloroform and then with ethyl acetate to yield N-[4-(2-bromo-acetyl)-3-fluoro-phenyl]-acetamide (8.7 g, 43%); LCIMS at 254 nm; [M+H] 275; Rt 2.918 min)

후처리

  1. filtrationSubsequently the precipitated product is filtered off
  2. washwashed first with chloroform

출처 및 근거

ORD 기록
ord-36ad943755504f6d9a194d0e76d4286b
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786155B2

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