N-bromobutanimide → 4-Bromo-2-(bromomethyl)-1-fluorobenzene

HRID 50744

반응식

HRID 50744 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:9])=[C:6]([CH3:8])[CH:7]=1.C1C(=O)N([Br:17])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:9])=[C:6]([CH:7]=1)[CH2:8][Br:17]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 1235275-Bromo-2-fluorotoluene

생성물 1

HCID 135532954-Bromo-2-(bromomethyl)-1-fluorobenzene

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To a solution of 5-bromo-2-fluorotoluene (15 g, 0.079 mole) in CCl4 (150 mL) was added NBS (14.2 g, 0.080 mole). The resulting reaction solution was heated under reflux with the starting material being completely consumed within 2 hr. CCl4 was removed under reduced pressure and the residue was diluted, dissolved in ether, washed with brine (3×), dried over MgSO4, and concentrated. Chromatography in hexane yielded 5-bromo-2-fluorobenzyl bromide. The product was immediately used for the reaction below.

후처리

  1. customThe resulting reaction solution
  2. temperaturewas heated
  3. temperatureunder reflux with the starting material
  4. custombeing completely consumed within 2 hr
  5. customCCl4 was removed under reduced pressure
  6. additionthe residue was diluted
  7. dissolutiondissolved in ether
  8. washwashed with brine (3×)
  9. dry with materialdried over MgSO4
  10. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a0a7822fbbeb4afd8b2e3c1c1581a734
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713478B2

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