Hydrochloric Acid → 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole

HRID 507513노트

반응식

HRID 507513 반응식
[O:1]=[C:2]1[N:6]([CH2:7][CH2:8][NH:9]C(=O)OC(C)(C)C)[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[NH:3]1.Cl>C(OCC)C>[NH2:9][CH2:8][CH2:7][N:6]1[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[NH:3][C:2]1=[O:1]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57428815tert-Butyl 2-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)ethylcarbamate

생성물 1

HCID 117451761-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

tert-Butyl 2-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)ethylcarbamate (200 mg) was added to 15 mL of hydrogen chloride solution in diethyl ether (1 M) and the mixture was stirred at rt for 5 h. Evaporation of the solvent give the title compound as a white hydrochloride salt (100%).

후처리

  1. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-01e96bcf7dab41fc867ccac764bceff9
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786132B2

반응 노트

불러오는 중…